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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9040 | Aurora kinase inhibitor-2 | IUN-70219,Aurora Kinase Inhibitor II | Aurora Kinase |
Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M). | |||
T6435 | CCT129202 | Aurora Kinase | |
CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively. It is less potent to FGFR3, GSK3β, PDGFRβ, etc. | |||
T2241 | Alisertib | MLN 8237 | Apoptosis , Aurora Kinase , Autophagy |
Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B. | |||
T8537 | Tripolin A | Aurora Kinase | |
Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively) | |||
T17267 | XL228 | IGF-1R , Bcr-Abl , Src , Aurora Kinase | |
XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively). | |||
T64338 | AKI603 | AKI 603,AKI-603 | Aurora Kinase |
AKI603 is a novel small molecule inhibitor of Aurora kinase A (AurA)(IC50 = 12.3 nM). AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in l... | |||
T62647 | Aurora A inhibitor 2 | ||
Aurora A inhibitor 2 (Compound 16h) is a potent inhibitor of Aurora A kinase (IC50: 21.94 nM). | |||
T36932 | CD532 hydrochloride | ||
CD532 hydrochloride is a potent inhibitor of Aurora A kinase, having an IC50 of 45 nM. It not only blocks the activity of Aurora A kinase but also facilitates the degradation of the protein MYCN. Furthermore, CD532 hydro... | |||
T36801 | Binucleine 2 | ||
Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 μM), a kinase involved in cell division. It is specific for Drosophila Aurora B kinase, inhibiting it in a dose-d... | |||
T36199 | AZD 1152 (hydrochloride) | ||
AZD 1152 is an orally bioavailable prodrug of AZD 1152-HQPA, a selective inhibitor of Aurora kinase B (IC50= 0.36 nM).1AZD 1152 is converted to AZD 1152-HQPA in plasma. Inhibition of Aurora B results in disruption of spi... | |||
T61061 | JH295 hydrate | ||
JH295 hydrate is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor that inhibits cellular Nek2 by Cys22 alkylation (IC50 = 770 nM). JH295 hydrate is not active against the mitotic kinases, Cdk1,... | |||
T38710 | JH295 | ||
JH295 is a highly potent and selective inhibitor of NIMA-related kinase 2 (Nek2), exhibiting irreversible inhibition activity with an IC 50 value of 770 nM. This compound effectively inhibits cellular Nek2 using the alky... |